CometWiki

CometWiki

This site describes the set up and usage of `comet', an actin-based bead motility simulator. Actin is a polymer built by cells that allows them to move. Actin-based bead motility is an in vitro model system used to study how our cells produce force and move, carried out by coating a bead with proteins that tell the cell to polymerize actin, and putting the bead a solution that mimics the material inside cells. This causes an actin network to build around the bead. Surprisingly even when the bead is spherically symmetric, rather than just buiding a symmetric shell that gets bigger and bigger, it moves off in 'comet tail' of actin. This bead motility simulater aims to help us understand how this process works. Here are some examples of the simulator output: http://www.dayel.com/comet/supmat/movies/thumbnails/FigS2_Fig1_x_proj.mov.png http://www.dayel.com/comet/supmat/movies/thumbnails/FigS3_Fig1vtkx1.mov.png http://www.dayel.com/comet/supmat/movies/thumbnails/FigS7b_Symmetric_Capsule.mov.png More examples Essential Information Installing the program comet runs on any unix-like operating system, including OS X, Linux or Windows. Instructions for downloading and installing comet Running the program The program is called from the command line. The command line parameters tell the program what to do (calculate a new run, re-process existing data, interactive 3D view etc.). A cometparams.ini file in the working directory tells the program detailed information about the model parameters to use for calculation and display. Command line parameters for the comet program Model settings in the cometparams.ini file Display settings in the cometparams.ini file Running comet on a cluster How the program works Overview of How the comet program works Implementation In Depth Model Robustness Tracking network movement and making measurements

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